1017 NEUROPSYCHIATRIC GENETICS: THE LAST ‘BLACK BOX’ OF GENETIC RESEARCH
Dr Nathaniel McGregor, lecturer, Systems Genetics Working Group, Human Genetics, Stellenbosch University
Mental health disorders are debilitating conditions that affect hundreds of millions globally. This course will introduce the genetics and epigenetics associated with the manifestation of mental health disorders, focusing on anxiety disorders and schizophrenia. It will discuss disorder aetiology, heritability, environmental aspects and the interaction of these in terms of manifestation and subtypes of disease. The course does not aim to answer all the questions surrounding the molecular aetiology of mental health disorders, but to present current views on these conditions. It will show that researchers may be asking the ‘right’ questions with regard to future developments.
1. Mental health disorders: molecular aetiology and prevalence
2. Heritability in mental health disorders
3. Gene-environment correlation vs. gene-environment interaction
4. The importance of regulatory mechanisms in neuropsychiatric genetic research
5. Asking the right questions and future developments
Bantjes, J. et al. 2017. Monitoring outcomes is key to improving mental health treatment in South Africa.
McGregor,N. 2015. New gene links to schizophrenia could open the door to improved treatments.
McGregor, N. 2015. Seven new genes linked to anxiety disorders.